jyi.orgJournal of Young Investigators

-- Journals Current Issue Archived Issues Special Issues Join JYI or Submit a Manuscript Get Involved Submit Your Research Join Our Team Faculty Advisors Sponsor Us Research Articles Recent Publications Archived Research Opportunities Submit Research News & Careers Articles News Archived News & Careers Career Center About About JYI Our Team What We Do Our Mission Our History Pressroom JYI Blog Blog Home All Posts Voices of JYI Voices of the BoD JYI Webinars Contact Us Journals Current Issue Archived Issues Special Issues Join JYI or Submit a Manuscript Get Involved Submit Your Research Join Our Team Faculty Advisors Sponsor Us Research Articles Recent Publications Archived Research Opportunities Submit Research News & Careers Articles News Archived News & Careers Career Center About About JYI Our Team What We Do Our Mission Our History Pressroom JYI Blog Blog Home All Posts Voices of JYI Voices of the BoD JYI Webinars Contact Us The : Innovation in scientific writing, publishing, and peer-review for undergraduates. Current Issue Blog Get Involved Submit As the COVID-19 pandemic spreads, we at JYI would like to keep you updated on everything that’s going on and what you can do to stay safe. Visit our COVID-19 coverage page. The Undergraduate Research Journal Best of JYI 2019 Submit to the Best of JYI 2019 Abstract and Photo Competitions Find Out More Featured Research 2020, April Apr 1, 2020 Analysis of expression of MSH2 and MSH3 genes in Mixed Lineage Leukemia (MLL)-Acute Lymphoblastic Leukemia (ALL) human cell lines Apr 1, 2020 Around 803 new cases of Acute Lymphoblastic Leukemia (ALL) are diagnosed in the United Kingdom every year (Cancer Research UK, 2018). Cytarabine (Ara-C) is a chemotherapeutic drug used to treat leukemic patients, however, chemotherapy resistance occurs frequently. Mechanisms of chemotherapy resistance to Ara-C are poorly understood. DNA mismatch repair (MMR) pathway is one of the pathways responsible to repair errors caused during DNA replication. MMR can also repair damage due to Ara-C and therefore a proficient MMR can confer resistance to Ara-C. Our project aims to investigate the expression of MMR genes MSH2 and MSH3 in ALL carrying Mixed Lineage Leukemia (MLL), also known as KMT2A, chromosomal translocations. Apr 1, 2020 Press Releases Featured Apr 3, 2020 Press Release: The Role of DNA Mismatch Repair Genes in Chemotherapy Resistance Apr 3, 2020 In their recently published research paper, Kulsom Nuuri and Dr. Yoana Arroyo-Berdugo from the University of Roehampton presented their investigation of the origin of chemotherapy resistance in pediatric patients suffering from acute lymphoblastic leukemia (ALL). In ALL, large numbers of lymphoblasts develop from stem cells in the bone marrow and quickly crowd out other blood cells that are important for fighting infection, transporting oxygen, and clotting. Eventually, these cancerous cells spread to the blood and other organs. Without treatment, ALL can be fatal within just a few months. Apr 3, 2020 News Features 2020, April Apr 5, 2020 Epigenetics Misregulation and Obesity or Epigenetics: Another Important Piece in the Obesity Puzzle Apr 5, 2020 In 2016, the World Health Organization (WHO) estimated that 1.9 billion individuals over the age of 18 are overweight which comprises roughly one-third of the world population. Obesity is defined by the presence of abnormal or excessive fat which presents excessive risks to an individual’s health. Consequently, obesity is a risk factor for diseases such as cardiovascular disease, diabetes, and cancer. Health care professionals and world organization bodies, such as the WHO, highlight that obesity is preventable. As such, there has been significant research conducted to understand the causes of the pandemic. Apr 5, 2020 Science Careers 2020, March Mar 1, 2020 The Work of an Experimental Physicist at ATLAS: An Interview with Dr. Evelyn Thomson Mar 1, 2020 The quest to understand the natural world is of paramount importance and takes the dedication of many driven minds. One part of this journey is the demystification of the Higgs boson, an elementary particle that gives all matter mass. Such a particle is amongst many others being studied by physicists today, an effort bolstered by Dr. Evelyn Thomson, an experimental particle physicist at the University of Pennsylvania. Mar 1, 2020 Interested in submitting your research to the journal? Learn How Follow Us: Our mission is to improve undergraduate science training by providing innovative, high-quality educational experiences in science writing, publication and the peer-review process. Manuscript Guidelines Stay up-to-date on news and publications: Join JYI's Listserv → Back to Top Staff Tools | Contact Us | Privacy Policy | Terms © 1998-2019 . All rights reserved. ISSN 1539-4026...